A 4.2-magnitude quake struck south of Ierapetra, on the Greek island of Crete, shortly after 1am local time on Sunday.
The quake was 10km deep, according to the Greek Institute of Geodynamics. There were no immediate reports of injuries or damage.
The Mediterranean region is seismically active due to the northward convergence (4-10 mm/yr) of the African plate with respect to the Eurasian plate along a complex plate boundary. Greece lies within this seismically active area.
Earthquakes have historically caused widespread damage across central and southern Greece, the island of Crete, Cyprus, Sicily and other neighboring regions.
In January, a series of strong earthquakes on the western island of Kefalonia damaged hundreds of homes and injured more than a dozen people.