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Greek Scientist Makes Breakthrough in Diagnosing the Ebola Virus

Dr Sterghios Moschos working in the lab

A new, faster and safer way of diagnosing the Ebola virus has been developed by a Greek academic from Northumbria University in the UK.

Research led and carried out by Dr Sterghios Moschos at Northumbria means that patients with Ebola-like symptoms can be identified and treated much sooner and at the point of care, helping to reduce the spread of the disease and risks to others.

During the Ebola outbreak in Africa in 2014, patients tested for the disease had to provide a blood sample fortesting in a specialist lab by highly trained staff. There are only a few of these facilities in the world, including Public Health England’s Lab in Porton Down in the UK, with each diagnosis of the Ebola virus genome taking between 5-8 hours to confirm.

Thanks to the efforts of Dr Moschos’ research team, working with a manufacturer of innovative diagnostic solutions, a new point of care diagnostic platform – EbolaCheck—has been developed, which can be deployed to the scene of an outbreak.

The test can now be carried out on an amount of blood that is 700 times smaller than previously needed—literally a drop obtained by ‘pin pricking’ a finger—and it now takes less than 70 minutes to complete.

As a result, the test is much safer to administer, requires minimal training and reduces the cost of diagnosis significantly. Crucially, its performance is comparable to laboratory testing, meaning any patient with symptoms of Ebola can be safely and reliably diagnosed.

Dr Sterghios A. Moschos, Associate Professor of Cellular and Molecular Sciences at Northumbria University, led the research. He said: “During the Ebola outbreak, between 2013 & 2016, over 28,500 individuals contracted the disease with a mortality rate of 39.5%. These people often had to walk for hours to reach overflowing treatment centres, or wait for days for samples to be processed. Some were put at risk having to wait next to probable Ebola virus cases for an ‘all clear’- usually because the symptoms of other diseases, like malaria, made them fear they had the Ebola virus.

“The development of this pioneering technology could essentially save lives and reduce the spread of the disease, which is crucial in a humanitarian crisis. Due to there being no further cases since it was developed, to date, it has not been possible to take the test out of the lab, into the field, where the patient needs it. However, it can be deployed anywhere—the frontline in Africa where this disease is found, as well as international airports and ports—to help stop the disease from spreading and to prevent disruption of international trade and travel. It could also be used in the diagnosis of other infectious diseases, as well as bringing genetic testing to the shop front, for example in a pharmacy or a GP surgery.”

Dr Moschos’ research findings are published in The Royal Society of Chemistry’s Chemical Science.


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